Table 1.
Detailed demographics and baseline comorbidities of patients undergoing TAVI for tricuspid versus bicuspid valvular aortic disease
| Crude analysis | Propensity matched analysis | |||
|---|---|---|---|---|
| TAV (214,050) | BAV (2673) | TAV (2674) | BAV (2673) | |
| Age | 80.18 ± 8.4 | 67.91 ± 14.25 | 68.19 ± 14.4 | 67.91 ± 14.2 |
| Sex | ||||
| Male | 114,069 (53.30%) | 1668 (62.40%) | 1610 (60.20%) | 1668 (62.40%) |
| Female | 99,960 (46.70%) | 1005 (37.60%) | 1064 (39.80%) | 1005 (37.60%) |
| Race | ||||
| White | 177,314 (87.00%) | 2214 (86.70%) | 2209 (82.60%) | 2214 (82.80%) |
| Black | 8503 (4.20%) | 100 (3.90%) | 80 (3.00%) | 100 (3.70%) |
| Hispanic | 9597 (4.70%) | 80 (3.10%) | 170 (6.40%) | 80 (3.00%) |
| Asian or Pacific Islander | 2575 (1.30%) | 85 (3.30%) | 40 (1.50%) | 85 (3.20%) |
| Native American | 485 (0.20%) | <11 | <11 | <11 |
| Other | 5428 (2.70%) | 65 (2.50%) | 65 (2.40%) | 65 (2.40%) |
| Admission | ||||
| Weekday | 204,301 (95.40%) | 2554 (95.50%) | 2554 (95.50%) | 2554 (95.50%) |
| Weekend | 9749 (4.60%) | 120 (4.50%) | 120 (4.50%) | 120 (4.50%) |
| Region Old | ||||
| Northeast | 51,242 (23.90%) | 514 (19.20%) | 570 (21.30%) | 514 (19.20%) |
| Midwest | 48,441 (22.60%) | 670 (25.10%) | 600 (22.40%) | 670 (25.10%) |
| South | 72,737 (34.00%) | 825 (30.80%) | 959 (35.90%) | 825 (30.80%) |
| West | 41,629 (19.40%) | 665 (24.90%) | 545 (20.40%) | 665 (24.90%) |
| Category | ||||
| Government or private (collapsed category) | 1156 (0.50%) | 14 (0.50%) | <11 | 14 (0.50%) |
| Government, nonfederal (public) | 15,995 (7.50%) | 245 (9.20%) | 195 (7.30%) | 245 (9.20%) |
| Private, not‐for‐profit (voluntary) | 178,624 (83.40%) | 2250 (84.10%) | 2230 (83.40%) | 2250 (84.10%) |
| Private, investor‐owned (proprietary) | 18,275 (8.50%) | 165 (6.20%) | 240 (9.00%) | 165 (6.20%) |
| Hospital | ||||
| Urban nonteaching | 20,334 (9.50%) | 240 (9.00%) | 220 (8.20%) | 240 (9.00%) |
| Urban teaching | 191,911 (89.70%) | 2434 (91.00%) | 2439 (91.20%) | 2434 (91.00%) |
| Small | 13,200 (6.20%) | 170 (6.40%) | 130 (4.90%) | 170 (6.40%) |
| Medium | 40,885 (19.10%) | 470 (17.60%) | 500 (18.70%) | 470 (17.60%) |
| Large | 159,964 (74.70%) | 2033 (76.10%) | 2044 (76.40%) | 2033 (76.10%) |
| Region New | ||||
| New England | 11,610 (5.40%) | 190 (7.10%) | 145 (5.40%) | 190 (7.20%) |
| Middle Atlantic | 39,140 (18.30%) | 315 (11.80%) | 425 (15.90%) | 315 (11.90%) |
| East North Central | 32,450 (15.20%) | 440 (16.50%) | 450 (16.90%) | 440 (16.60%) |
| West North Central | 15,760 (7.40%) | 230 (8.60%) | 150 (5.60%) | 230 (8.70%) |
| South Atlantic | 41,570 (19.40%) | 450 (16.80%) | 510 (19.10%) | 450 (16.90%) |
| East South Central | 11,635 (5.40%) | 155 (5.80%) | 150 (5.60%) | 155 (5.80%) |
| West South Central | 19,165 (9.00%) | 215 (8.00%) | 290 (10.90%) | 215 (8.10%) |
| Mountain | 12,750 (6.00%) | 280 (10.50%) | 185 (6.90%) | 280 (10.50%) |
| Pacific | 28,770 (13.40%) | 380 (14.20%) | 360 (13.50%) | 380 (14.30%) |
| Comorbidities | ||||
| Diabetes mellitus | 26,960 (12.60%) | 300 (11.20%) | 220 (8.20%) | 300 (11.20%) |
| Hypertension (HTN) | 186,288 (87.00%) | 2074 (77.60%) | 1979 (74.00%) | 2074 (77.60%) |
| HTN uncomplicated | 70,949 (33.10%) | 890 (33.30%) | 995 (37.20%) | 890 (33.30%) |
| HTN complicated | 116,674 (54.50%) | 1200 (44.90%) | 1005 (37.60%) | 1200 (44.90%) |
| Coronary artery disease | 147,288 (68.80%) | 1479 (55.30%) | 1470 (55.00%) | 1479 (55.30%) |
| Smoking | 8882 (4.10%) | 255 (9.50%) | 265 (9.90%) | 255 (9.50%) |
| Atrial fibrillation | 89,073 (41.60%) | 835 (31.20%) | 890 (33.30%) | 835 (31.20%) |
| Opioid use | 300 (0.10%) | <11 | <11 | <11 |
| Vasopressin use | 4563 (2.10%) | 70 (2.60%) | 45 (1.70%) | 70 (2.60%) |
| Myocardial infarction | 32,685 (15.30%) | 325 (12.10%) | 380 (14.20%) | 325 (12.10%) |
| Alcohol use | 727 (0.30%) | <11 | 15 (0.60%) | <11 |
| Cerebrovascular disease | 25,259 (11.80%) | 270 (10.10%) | 275 (10.30%) | 270 (10.10%) |
| Arrhythmias | 98,065 (45.80%) | 1180 (44.10%) | 1160 (43.40%) | 1180 (44.10%) |
| Heart failure | 157,691 (73.70%) | 1790 (67.00%) | 1735 (64.90%) | 1790 (67.00%) |
| Coagulopathy | 29,790 (13.90%) | 385 (14.40%) | 335 (12.50%) | 385 (14.40%) |
| COPD | 72,017 (33.60%) | 844 (31.60%) | 835 (31.20%) | 844 (31.60%) |
| Iron deficiency anemia | 8120 (3.80%) | 85 (3.20%) | 55 (2.10%) | 85 (3.20%) |
| Depression | 16,162 (7.60%) | 310 (11.60%) | 320 (12.00%) | 310 (11.60%) |
| Drug use | 925 (0.40%) | 45 (1.70%) | 40 (1.50%) | 45 (1.70%) |
| Electrolyte abnormalities | 38,604 (18.00%) | 569 (21.30%) | 550 (20.60%) | 569 (21.30%) |
| ESRD | 8178 (3.80%) | 45 (1.70%) | 135 (5.00%) | 45 (1.70%) |
| Hypothyroidism | 43,225 (20.20%) | 385 (14.40%) | 445 (16.60%) | 385 (14.40%) |
| Liver disease | 6851 (3.20%) | 195 (7.30%) | 215 (8.00%) | 195 (7.30%) |
| Lymphoma | 1619 (0.80%) | 20 (0.70%) | 50 (1.90%) | 20 (0.70%) |
| Metastatic cancer | 1270 (0.60%) | 45 (1.70%) | 70 (2.60%) | 45 (1.70%) |
| Neurologic disorder | 6518 (3.00%) | 85 (3.20%) | 85 (3.20%) | 85 (3.20%) |
| Obesity | 28,895 (13.50%) | 415 (15.50%) | 415 (15.50%) | 415 (15.50%) |
| Paralysis | 2235 (1.00%) | 40 (1.50%) | 35 (1.30%) | 40 (1.50%) |
| Peripheral vascular disease | 48,369 (22.60%) | 660 (24.70%) | 670 (25.10%) | 660 (24.70%) |
| Psychosis | 889 (0.40%) | 15 (0.60%) | 25 (0.90%) | 15 (0.60%) |
| Pulmonary circulation disorder | 41,024 (19.20%) | 540 (20.20%) | 440 (16.50%) | 540 (20.20%) |
| Renal failure | 77,733 (36.30%) | 680 (25.40%) | 665 (24.90%) | 680 (25.40%) |
| Rheumatoid | 9837 (4.60%) | 85 (3.20%) | 145 (5.40%) | 85 (3.20%) |
| Solid tumor | 4594 (2.10%) | 95 (3.60%) | 60 (2.20%) | 95 (3.60%) |
| Weight loss | 7762 (3.60%) | 140 (5.20%) | 125 (4.70%) | 140 (5.20%) |
| All anemias | 36,175 (16.90%) | 340 (12.70%) | 330 (12.30%) | 340 (12.70%) |
| Blood loss anemia | 2441 (1.10%) | 30 (1.10%) | 25 (0.90%) | 30 (1.10%) |
Abbreviations: BAV, bicuspid aortic valve; COPD, chronic obstructive lung disease; ESRD, end stage renal disease; TAV, trileaflet aortic valve; TAVI, transcatheter aortic valve implantation.