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Dose‐dependent pharmacodynamic change of kynurenine. Kynurenine level at trough on C1D1 and C2D1 are shown in box graphs. Significance of difference from C1D1 to C2D1 was calculated using paired t test. Median levels are indicated. C1D1 indicates cycle 1 day 1; C2D1, cycle 2 day 1; ns, not significant. *p < .05.
