Table 1.
Hormone | Mechanism of action | Impact on hair |
---|---|---|
Androgens | Action via intracellular androgen receptor in the dermal papilla | Face, axilla, pubic, chest hair: transformation of vellus to terminal hairs |
Testosterone and dihydrotestosterone | 5‐α reductase inhibitor converts testosterone to the more potent dihydrotestosterone | Scalp hair: inhibitory |
Oestrogen | Binding to high‐affinity oestrogen receptors | Impact remains under investigation, but thought to prolong anagen phase and reduce telogen phase |
Progesterone | Central action: inhibits LH secretion, which reduces androgen synthesis | Further research is required to understand the impact of progesterone on the hair cycle. Possible action via androgens |
Hair follicle: inhibits 5‐α reductase (reduces conversion of testosterone to dihydrotestosterone) |
LH, luteinizing hormone.