TABLE 2.
Phase 2 and Phase 3 clinical trials with low molecular weight antagonists of Factor D or Factor B. Source: clinicaltrials.gov
| Compound | Indication | Phase | Comparator/combination | Identifier (status, 07/22) |
|---|---|---|---|---|
| A. Factor D inhibitors | ||||
|
Danicopan (Achillion/Alexion) |
PNH | 3 | C5 inhibitor co‐administration |
NCT04469465 (ALPHA, recruiting), NCT05389449 (not yet recruiting) NCT03472885 (active, not recruiting) |
| 2 | None |
NCT03053102 (completed) NCT03181633 (active, not recruiting) |
||
| C3G | 2 | None | NCT03369236 (completed) | |
| C3G or IC‐MPGN | 2 | None |
NCT03124368 (completed) NCT03459443 (completed) |
|
| Geographic Atrophy secondary to AMD | 2 | none | NCT05019521 (recruiting) | |
| COVID‐19 | 2 | Remdisivir | NCT04988035 (ACTIV‐5, BET‐C, completed) | |
| Vemircopan (Achillion/Alexion) | PNH | 2 | None | NCT04170023 (recruiting) |
| Myasthenia Gravis | 2 | None | NCT05218096 (recruiting) | |
| Proliferative Lupus Nephritis and IgAN | 2 | None | NCT05097989 (recruiting) | |
| BCX9930 (BioCryst) |
PNH |
2 | None |
NCT05116774 (REDEEM‐1; active, not recruiting) NCT05116787 (REDEEM‐2; active, not recruiting) NCT04702568 (active, not recruiting) NCT04330534 (completed) |
| C3G, IgAN and MN | 2 | None | NCT05162066 (RENEW; active, not recruiting) | |
| B. Factor B inhibitors | ||||
| Iptacopan (Novartis) | PNH | 3 | Anti C5 antibody head‐to‐head | NCT04558918 (APPLY‐PNH; active, not recruiting) |
| None |
(APPOINT‐PNH, recruiting) NCT04747613 (recruiting) |
|||
| 2 | C5 inhibitor co‐administration |
NCT03439839 (completed) |
||
| None |
NCT03896152 (completed) |
|||
| aHUS | 3 | None | NCT04889430 (APPELHUS; recruiting) | |
|
C3G |
3 | None | NCT04817618 (APPEAR‐C3G; recruiting) | |
| 2 | None |
NCT03955445 (recruiting) NCT03832114 (completed) |
||
|
IgAN |
3 | None |
NCT04578834 (APPLAUSE‐IgAN; recruiting) NCT04557462 (recruiting) |
|
| 2 | None | NCT03373461 (completed) | ||
| Autoimmune Benign Hematological Disorders (ITP and CAD) | 2 | None | NCT05086744 (recruiting) | |
| Lupus Nephritis | 2 | None | NCT05268289 (recruiting) | |
| AMD | 2 | None | NCT05230537 (recruiting) | |
| Idiopathic MN | 2 | None | NCT04154787 (recruiting) | |