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Graph depicting accumulation of the P‐gp substrate 99mTc‐MIBI in gall bladder over time in dogs homozygous for wildtype ABCB1 (open circles), heterozygote dogs (closed circles), or dogs homozygous for ABCB1‐1Δ (triangles). Note that there is no detectable biliary excretion of the P‐gp substrate in dogs homozygous for ABCB1‐1Δ. While heterozygotes have an intermediate level of biliary excretion of the P‐gp substrate. Reprinted with permission (Coelho et al., 2009).
