Table 4.

Associations of clonal haematopoiesis of indeterminate potential with incident heart failure, heart failure subtypes, according to age categories

	Individuals <65 years				Individuals ≥65 years
	CHIP HR (95% CI)	p‐value	DNMT3A HR (95% CI)	p‐value	CHIP HR (95% CI)	p‐value	DNMT3A HR (95% CI)	p‐value
Incident HF	2.07 (1.30–3.29)	0.002	2.13 (1.25–3.61)	0.005	0.95 (0.66–1.36)	0.773	1.29 (0.86–1.95)	0.220
Incident HFrEF	1.45 (0.79–2.66)	0.233	1.35 (0.66–2.76)	0.416	1.01 (0.65–1.58)	0.957	1.23 (0.74–2.06)	0.425
Incident HFpEF	2.11 (1.01–4.41)	0.048	2.26 (1.01–5.04)	0.047	0.78 (0.41–1.49)	0.447	1.10 (0.54–2.23)	0.789

CHIP, clonal haematopoiesis of indeterminate potential; CI, confidence interval; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio.

Cox regression models were adjusted for age, sex, smoking, diabetes, hypertension, body mass index, cholesterol, history of myocardial infarction, atrial fibrillation and cerebrovascular accident.