Table 5.

Associations of highest variant allele frequencies with incident heart failure and its subtypes

	Entire cohort				Individuals <65 years				Individuals ≥65 years
	VAF 2–5% HR (95% CI)	p‐value	VAF >5% HR (95% CI)	p‐value	VAF 2–5% HR (95% CI)	p‐value	VAF >5% HR (95% CI)	p‐value	VAF 2–5% HR (95% CI)	p‐value	VAF >5% HR (95% CI)	p‐value
Incident HF	1.29 (0.91–1.82)	0.147	1.16 (0.75–1.80)	0.506	1.98 (1.15–3.41)	0.014	2.30 (1.05–5.02)	0.037	1.04 (0.66–1.63)	0.864	0.84 (0.49–1.42)	0.510
Incident HFrEF	1.42 (0.94–2.14)	0.092	0.87 (0.48–1.57)	0.637	1.67 (0.87–3.22)	0.126	0.85 (0.20–3.49)	0.817	1.29 (0.75–2.19)	0.357	0.74 (0.38–1.44)	0.370
Incident HFpEF	0.83 (0.44–1.54)	0.549	1.67 (0.87–3.22)	0.123	1.32 (0.50–3.51)	0.573	4.74 (1.76–12.74)	0.002	0.62 (0.27–1.41)	0.254	1.10 (0.46–2.64)	0.837

CI, confidence interval; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio; VAF, variant allele frequency.

Cox regression models were adjusted for age, sex, smoking, diabetes, hypertension, body mass index, cholesterol, history of myocardial infarction, atrial fibrillation and cerebrovascular accident.