TABLE 2.

The values of hyper‐parameters resulting from the prior calibration procedure

	Setting 1	Setting 2
TITE‐CRM	${\sigma }^2=1$	${\sigma }^2=1$
	$d=(0.05,0.10,0.15,0.20,0.25,0.30)$	$d=(0.05,0.10,0.15,0.20,0.25,0.30)$
	$\text{ESS}\approx 2$	$\text{ESS}\approx 2$
TITE‐CRM2	${\mu }_{a_0}=-1$	${\mu }_{a_0}=-1$
	${\sigma }_{a_0}^{-2}=0.3$	${\sigma }_{a_0}^{-2}=0.3$
	${\mu }_{a_1}=\log (0.2)$	${\mu }_{a_1}=\log (0.2)$
	${\sigma }_{a_1}^{-2}=0.3$	${\sigma }_{a_1}^{-2}=0.3$
	$\text{ESS}\approx 1$	$\text{ESS}\approx 1$
ICSDP	$\pi {\ast }_1=0.2$	$\pi {\ast }_1=0.2$
	$\pi {\ast }_J=0.4$	$\pi {\ast }_J=0.3$
	$n_0=6$	$n_0=4$
	$\text{ESS}\approx 2$	$\text{ESS}\approx 1$
POMM	$p_1\ast =(0.15,0.20,0.25,0.3,0.35,0.40)$	$p_1\ast =(0.15,0.20,0.25,0.3,0.35,0.40)$
	$n_0=2$	$n_0=2$
	$p_1^{G2}/p_1=(0.20,0.30,0.40,0.50,0.60)$	$p_1^{G2}/p_1=(0.20,0.30,0.40,0.50,0.60)$
	$\text{ESS}\approx 2$	$\text{ESS}\approx 2$
nTTP	${\mu }_{{\beta }_0}=0.1$	${\mu }_{{\beta }_0}=0.05$
	${\sigma }_{{\beta }_0}^2=100$	${\sigma }_{{\beta }_0}^2=10$
	${\mu }_{{\beta }_1}=0.5$	${\mu }_{{\beta }_1}=0.1$
	${\sigma }_{{\beta }_1}^2=100$	${\sigma }_{{\beta }_1}^2=10$
	${\mu }_{{\beta }_2}=0$	${\mu }_{{\beta }_2}=0$
	${\sigma }_{{\beta }_2}^2=10$	${\sigma }_{{\beta }_2}^2=10$
	$\text{ESS}\approx 1$	$\text{ESS}\approx 1$
TITE‐BOIN	${\tau }_1=0.3128$ (equivalent to ${\lambda }_e=0.3512$)	${\tau }_1=0.3128$ (equivalent to ${\lambda }_e=0.3512$)
	${\tau }_2=0.5083$ (equivalent to ${\lambda }_d=0.4492$)	${\tau }_2=0.5083$ (equivalent to ${\lambda }_d=0.4492$)
	$\alpha =0.1$	$\alpha =1$
	$\beta =0.9$	$\beta =1$
	$\text{ESS}\approx 1$	$\text{ESS}\approx 2$
TITE‐mTPI2	${\tau }_1=0.3519$	${\tau }_1=0.3519$
	${\tau }_2=0.5474$	${\tau }_2=0.5474$
	$\text{ESS}\approx 2$	$\text{ESS}\approx 2$
R‐mTPI2	${\tau }_1=0.3519$	${\tau }_1=0.3519$
	${\tau }_2=0.5474$	${\tau }_2=0.5474$
	$\text{ESS}\approx 2$	$\text{ESS}\approx 2$

Note: This corresponds to a target toxicity of 0.391 over 3 cycles. ESS is the average effective sample size per dose level.