TABLE 6.

Setting 2, $\tau =0.391$: Summary of stopping reasons for setting 2, expressed as a percentage of simulations where the given stopping rule was triggered

	TITE‐CRM	TITE‐CRM2	ICSDP	POMM	nTTP	TITE‐BOIN	TITE‐mTPI2	R‐mTPI2
Stopping reason	Scenario A
Sufficient information	57	46	88	60	46	68	70	68
Lowest dose deemed unsafe	42	50	11	20	22	28	30	32
Highest dose deemed too safe	0	0	0	0	0	0	0	0
Precision	0	17	2	14	73	0	0	0
Hard safety	10	4	11	14	10	3	4	4
Maximum patients	2	1	1	2	0	7	1	1
Unsafe (total)	42	50	11	26	25	28	30	32
Sufficient/precision (total)	58	50	89	71	75	68	70	68
Stopping reason	Scenario B
Sufficient information	65	65	83	35	32	77	89	70
Lowest dose deemed unsafe	4	11	1	1	1	6	6	8
Highest dose deemed too safe	0	1	0	0	0	2	1	1
Precision	34	21	21	72	96	0	0	0
Hard safety	1	0	1	1	1	0	0	0
Maximum patients	7	17	9	2	0	29	8	27
Unsafe (total)	4	11	1	2	1	6	6	8
Sufficient/precision (total)	94	79	95	97	98	77	89	70
Stopping reason	Scenario C
Sufficient information	37	24	70	42	20	49	49	47
Lowest dose deemed unsafe	63	73	29	38	71	48	51	53
Highest dose deemed too safe	0	0	0	0	0	0	0	0
Precision	0	19	1	6	32	0	0	0
Hard safety	24	10	29	30	21	9	10	10
Maximum patients	1	0	1	2	0	6	1	0
Unsafe (total)	63	73	29	50	72	48	51	53
Sufficient/precision (total)	37	27	71	48	28	49	49	47
Stopping reason	Scenario D
Sufficient information	96	64	63	5	8	99	99	99
Lowest dose deemed unsafe	0	1	0	0	0	1	1	1
Highest dose deemed too safe	0	0	0	0	0	0	0	0
Precision	0	44	60	99	100	0	0	0
Hard safety	0	0	0	0	0	0	0	0
Maximum patients	13	4	0	0	0	1	1	1
Unsafe (total)	0	1	0	0	0	1	1	1
Sufficient/precision (total)	96	98	100	100	100	99	99	99

Note: The sum of these may be greater than 100, since it is possible for more than one rule to be triggered in a single trial.