TABLE 1.
Characteristics of HCV antibody‐positive persons with inherited bleeding disorders at their last clinical evaluation
| Spontaneous clearance | Ever diagnosed with chronic HCV | |
|---|---|---|
| Number | 73 | 309 a |
| Total number of follow‐up years | 2944 | 12,839 |
| Median follow‐up (years) | 41 (35–50) | 44 (34–50) |
| Male sex | 71 (97%) | 297 (96%) |
| Diagnosis | ||
| Haemophilia A | 54 (74%) | 250 (81%) |
| Haemophilia B | 11 (15%) | 42 (14%) |
| Von Willebrand disease | 6 (8%) | 8 (3%) |
| Other b | 2 (3%) | 9 (3%) |
| Severe bleeding disorder | 53 (73%) | 234 (76%) |
| Age at HCV infection (years) | 6 (1–22) | 8 (2–18) |
| Age at end of follow‐up (years) | 51 (40–63) | 52 (43–63) |
| HCV genotype | ||
| 1 c | 178 (58%) | |
| 2 | 29 (9%) | |
| 3 | 26 (8%) | |
| 4 | 7 (2%) | |
| 5 | 2 (1%) | |
| Unknown | 73 (100%) | 67 (22%) |
| HIV infection | 7 (10%) | 48 (16%) |
| HBV infection | ||
| HBsAg positive | 4 (6%) | 6 (2%) |
| HBsAg negative, anti‐HBc positive | 23 (32%) | 122 (40%) |
| History of severe alcohol use d | 5 (7%) | 37 (12%) |
| Body Mass Index (kg/m2) | 26 (24–28) | 25 (22–27) |
| At least advanced fibrosis e | 2 (3%) f | 110 (36%) |
| Child–Pugh A/B/C | 1/1/0 | 74/26/10 |
| Alanine transaminase (IU/L) | 22 (16–27) | 28 (18–52) |
| Aspartate transaminase (IU/L) | 24 (20–29) | 26 (18–43) |
| Platelet count (*109/L) | 236 (208–304) | 215 (156–262) |
| Bilirubin (μmol/L) | 10 (7–13) | 11 (8–16) |
| Albumin (g/L) | 42 (38–43) | 42 (38–45) |
| International normalised ratio | 1.0 (1.0–1.1) | 1.0 (1.0–1.1) |
Data are number (percentage) or median (interquartile range) unless otherwise noted. Anti‐HBc, hepatitis B core antibodies; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus.
One individual spontaneously cleared HCV after >20 years of chronic infection.
bDeficiency factor II (n = 1), VII (n = 1), X (n = 4), XIII (n = 2), or haemophilia carrier (n = 2).
cSubtypes: 1a n = 53, 1a/b n = 5, 1b n = 74, 1c n = 1, unknown n = 45.
dAlcohol intake > 20 units/week.
eFibroscan ≥ 9.5 kPa or radiological, histological or clinical diagnosis.
fBoth were diagnosed with alcoholic cirrhosis.