TABLE 2.
Liver‐related complications and mortality after median 44 years since HCV infection in HCV antibody‐positive persons with inherited bleeding disorders
| Complete cohort | Ever diagnosed with chronic HCV | |||
|---|---|---|---|---|
| Number | 382 | 309 | ||
| Spontaneous clearance | Ever diagnosed with chronic HCV | HIV/HCV | HCV mono | |
| Number | 73 | 309 | 48 | 261 |
| Data are reported as number (percentage, 95% confidence interval) | ||||
| Liver‐related complication | 1 a (1, 0–7) | 42 (14, 10–18) | 16 (33, 20–48) | 26 (10, 7–14) |
| Decompensated cirrhosis | 1 (1, 0–7) | 31 (10, 7–14) | 15 (31, 19–46) | 16 (6, 4–10) |
| Hepatocellular carcinoma | 1 (1, 0–7) | 17 (6, 3–9) | 2 (4, 1–14) | 15 (6, 3–9) |
| Gastroesophageal bleeding | 1 (1, 0–7) | 10 (3, 2–6) | 2 (4, 1–14) | 8 (3, 1–6) |
| Liver transplantation | 0 | 4 (1, 0–3) | 0 | 4 (2, 0–4) |
| All‐cause mortality | 14 (19, 10–30) | 83 (27, 22–32) | 29 (60, 45–74) | 54 (21, 16–26) |
| HIV/AIDS | 2 (3, 0–10) | 18 (6, 3–9) | 18 (38, 24–53) | 0 |
| Liver‐related | 1a (1, 0–7) | 23 (7, 5–11) | 10 (21, 10–35) | 13 (5, 3–8) |
| Non‐variceal haemorrhage | 1 (1, 0–7) | 11 (4, 2–6) | 0 | 11 (4, 2–7) |
| Malignancy b | 4 (5, 2–13) | 7 (2, 1–5) | 0 | 7 (3, 1–5) |
| Other | 4 (5, 2–13) | 16 (5, 3–8) | 0 | 16 (6, 4–10) |
| Unknown | 2 (3, 0–10) | 8 (3, 3–8) | 1 (2, 0–11) | 7 (3, 1–5) |
AIDS, acquired immune deficiency syndrome; HCV, hepatitis C virus; HIV, human immunodeficiency virus.
aDiagnosed with alcoholic cirrhosis.
bMalignancies not related to either HIV or HCV.