Table 1.

Summary of pre- and post-norepinephrine signal amplitudes and time course (T₈₀) for norepinephrine clearance following pressure-ejection of norepinephrine and treatments into dentate gyrus.

		Vehicle	Desipramine (54 pmol)	Venlafaxine (54 pmol)	Desipramine (108 pmol)	Vehicle	Desipramine (54 pmol)	Venlafaxine (54 pmol)	Desipramine (108 pmol)
		Vehicle	Vehicle	Vehicle	Vehicle	Decynium-22	Decynium-22	Decynium-22	Decynium-22
Ampl (μM)	Pre	0.8 ± 0.06	0.7 ± 0.05	0.7 ± 0.06	0.8 ± 0.31	0.7 ± 0.03	0.7 ± 0.06	0.8 ± 0.11	0.8 ± 0.18
	Post	0.8 ± 0.11	0.7 ± 0.09	0.6 ± 0.09	0.8 ± 0.14	0.6 ± 0.05	0.8 ± 0.11	0.9 ± 0.15	0.7 ± 0.21
T80 (s)	Pre	110 ± 7.2	106 ± 8.5	102 ± 11.4	65 ± 13.9	116 ± 10.3	111 ± 15.8	100 ± 10.9	96 ± 29.9
	Post	111 ± 9.9	118 ± 9.9	105 ± 12.3	142 ± 28.4a	119 ± 12.8	143 ± 17.1a	117 ± 13.1	322 ± 107b

Pre- and post-drug values for peak signal amplitude, and clearance time after local application of vehicle (PBS), desipramine (54 and 108 pmol), decynium-22 (1.4 pmol), venlafaxine (54 pmol), or combination of decynium-22 given with desipramine or venlafaxine.

^aP < 0.05 represents post-drug values being significantly different from pre-drug values (paired t-test).

^bP = 0.06. Mean ± S.E.M.; n = 6–13 group.