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The potency (ED50) and maximal anti-immobility effects (Emax) for venlafaxine when administered alone or with decynium-22 in the tail suspension test.
| Vehicle | Decynium-22 (0.1 mg/kg) | Decynium-22 (0.32 mg/kg) | |
|---|---|---|---|
| Venlafaxine | |||
| ED50 (mg/kg) | 3.6 | 5.0 | 9.2a |
| Emax (% control) | 76 ± 7 | 55 ± 10 | 53 ± 12 |
Mean ± S.E.M.
P < 0.05 different from venlafaxine/vehicle group (F ratio test); n = 8–12.
