FIGURE 2.

Relationship between galactose‐alpha‐1,3, galactose specific IgE and total IgE stratified by dairy tolerance among patients with alpha‐gal syndrome, University of North Carolina Allergy Clinic, 2010–2019. Dairy product‐tolerant visualizations (center and right panels) represent 54 paired total IgE and alpha‐gal sIgE tests among 54 patients who did not report AGS‐associated reactions to dairy products. Dairy product‐reactive visualizations (left and center panels represent 22 paired total IgE and alpha‐gal sIgE tests among 22 patients who reported AGS‐associated reactions to dairy products. Paired test results with a patient's highest recorded alpha‐gal sIgE value were selected for those with multiple pairs of tests. Right panel shows the distribution of alpha‐gal sIgE as a percentage of total IgE (scatter plots) with geometric mean and 95% confidence intervals depicted with black dot and lines; dairy‐reactive: GM (95% CI): 2.5 (1.3, 4.8)); non‐dairy: GM (95% CI): 4.1 (2.7, 6.1); difference (95% CI): 1.6 (−1.0, 3.9). Abbreviations: Alpha‐gal sIgE, alpha‐gal‐specific immunoglobulin E; CI, confidence interval; GM, geometric mean