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. 2022 Oct 27;128(24):4251–4284. doi: 10.1002/cncr.34479

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© 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Trends in age‐standardized incidence (2001–2018) and mortality (2001–2019) rates for pancreas cancer, for all racial/ethnic groups combined and all ages combined, are illustrated in (A) males and (B) females. Trends were estimated using joinpoint regression and characterized by using the annual percent change (APC), the slope of a single segment, and the average APC (AAPC), a summary measure of the APCs over a fixed 5‐year interval. Joinpoint models with up to three joinpoints are based on rates per 100,000 population and are age standardized to the 2000 US standard population (19 age groups; US Bureau of the Census. Current Population Report P25‐1130. US Government Printing Office; 2000). Incidence rates were delay‐adjusted and covered 92% of the US population, and mortality covered the entire United States. APCs and AAPCs with an asterisk (*) were statistically significantly different from zero (p < .05)