TABLE 2.
Pharmacokinetic parameters of CBD across all doses.
| Parameter | Dose (mg/kg) | |||||
|---|---|---|---|---|---|---|
| 2.5 | 5 | 10 | 20 | 40 | 80 | |
| Cmax (ng/ml) | 17.8 (3.2–45.3) | 61.1 (19.9–148.5) | 132.6 (43.2–258.4) | 281.0 (14.5–467.4) | 251.7 (47.4–467.0) | 963.9 (744.6–1126.8) |
| Tmax (h) | 2.0 (2.0–4.0) | 2.0 (2.0–4.0) | 2.0 (2.0–24.0) | 2.0 (2.0–4.0) | 2.0 (2.0) | 3.0 (2.0–6.0) |
| Half‐Life (h) | 13.2 a (12.8–13.5) | 8.2 (6.0–11.0) | 7.5 b (6.2–8.5) | 9.0 (5.7–14.9) | 9.6 (6.3–17.7) | 6.7 a (6.6–6.7) |
| AUC0‐24 (ng/ml × h) | 83.5 (8.1–165.9) | 437.1 (180.0–1139.2) | 1000.4 (460.8–1714.1) | 1481.0 (92.9–2372.9) | 1945.8 (313.1–4150.1) | 8738.1 (4269.6–10690.0) |
| CL/F (L/h/kg) | 12.6 a (12.3–13.0) | 17.4 (3.7–23.1) | 11.1 b (5.3–20.2) | 45.2 (8.5–84.6) | 37.3 (7.7–71.8) | 7.13 a (6.8–7.5) |
| MRT (h) | 4.5 (2.2–8.5) | 7.0 (5.9–8.1) | 9.0 (7.0–13.9) | 6.3 (7.2–8.1) | 7.5 (8.1–15.1) | 8.4 (7.6–9.4) |
| Vd/F (L/kg) | 239.7 a (239.6–239.8) | 196.9 (50.2–344.7) | 110.1 b (65.1–179.1) | 886.6 (73.1–3246.3) | 702.0 (89.0–2152.5) | 68.3 a (65.8–70.9) |
Note: A table listing pharmacokinetic parameters (Cmax, Tmax, Half‐Life, AUC0‐inf, CL/F, MRT, and Vd/F) for all doses. Values represent the mean value for four animals except where noted, and the range of the values is shown below in parentheses. Median Tmax is represented.
a
PK parameters could only be calculated for two of the four animals treated at this dose.
b
PK parameters could only be calculated for three of the four animals treated at this dose.