Impact of clinical factors and comorbidities on atrial fibrillation and sudden cardiac death in hypertrophic cardiomyopathy. HCM clinical variables associated with atrial fibrillation development (top) and sudden death events (bottom) in a large cohort of 2269 HCM patients (left). While obesity is associated with development of atrial fibrillation on univariate analysis, other comorbidities are not associated with atrial fibrillation development (top right), and obesity was not independently associated with AF development on multivariate analysis. Neither obesity or other comorbidities are associated with sudden death events (including appropriate ICD interventions for ventricular tachyarrhythmias, out of hospital cardiac events, or sudden death) (bottom right). *Associated with events on both univariate and multivariate analysis. †Associated with events on univariate but not on multivariate analysis. EF, ejection fraction; HCM, hypertrophic cardiomyopathy; LGE, late gadolinium enhancement; LV, left ventricular; NSVT, nonsustained ventricular tachycardia; SD, sudden death