The Geriatrics 5Ms of Mobility, Mind, Medications, Multicomplexity, and What Matters Most can help clinicians address polypharmacy among older adults, by addressing how each M domain impacts and is impacted by Medications.

The Age-Friendly Health Systems approach to medication management can help align medication use with what matters to the patient.

Further research is needed to study the impact of an Age-Friendly approach to polypharmacy in older adults and others across the lifespan.