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. 2023 Apr 12;14:2081. doi: 10.1038/s41467-023-37697-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Illustration of schedule of immunization, SARS-CoV-2 virus challenge and sacrifice for BALB/c mice. 6–8-week-old BALB/c mice were intranasally prime-boost vaccinated with Delta4N-DAF (2 × 10⁶ pfu) or Omi4N-DAF (2 × 10⁶ pfu) or PBS (n = 8 for each group) and then challenged with a mouse-adapted Omicron BA.1 SARS-CoV-2 strain (Omicron-MA, 1 × 10⁵ pfu) 4 weeks after boost immunization. B Body weight changes following virus challenge (n = 8 for each group). C Virus titers in the lungs were measured at 2 dpi (n = 4 for each group) and 4 dpi (n = 4 for each group). MA: mouse-adapted. LOD: lower limit of detection. Error bars represent mean ± SD. Statistical analysis was performed using one-way ANOVA followed by Dunn’s multiple comparisons test: ****p < 0.0001. Mouse cartoon created with BioRender.com.