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Primary bone marrow-derived precursors from Grk3−/− mice generate more osteoclasts ex vivo. (A) Total osteoclasts (>3 nuclei), (B) small osteoclasts (3–4 nuclei), (C) medium osteoclasts (5–8 nuclei) and (D) large osteoclasts (9+ nuclei) were significantly increased (* p < 0.5 and *** p < 0.001) after differentiation in RANKL, staining for TRAP, and enumeration.
