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Effect of Baicalein on different signaling pathways. The schematic view represents the molecular mechanisms of Baicalein inhibiting cell proliferation through the Notch/Hes pathway. Cells undergo apoptosis following the treatment of Baicalein, which hampers the signal transduction between Akt and NF-κB signaling pathways. CSCs lose their self-replicating feature after Baicalein treatment, downregulating the Shh receptor and effectors.
