Table 3.

Univariate and multivariate Cox proportional hazard regressions on chitotriosidase activity (nmol/mL/h) and neopterin levels (nmol/L) at presentation, adjusted for TNM stage and neoadjuvant chemotherapy.

	HR Unadjusted	(95% CI)	p	HR Adjusted *	(95% CI)	p
Neopterin (nmol/L)	1.002	(0.9659–1.04)	0.9	1.0012	(0.952–1.0523)	0.96
Chitotriosidase (nmol/mL/h)	1.001	(0.9988–1.003)	0.37	1.0038	(1.00023–1.007)	0.03
Neopterin ≥ median	0.62	(0.267–1.48)	0.29	0.52	(0.18–1.46)	0.22
Chitotriosidase ≥ median	1.038	(0.43–2.507)	0.99	3.101	(0.758–12.69)	0.11

HR—hazard ratio; 95% CI—95% confidence interval; * Adjusted for TNM stage (I + II, III, and IV) and neoadjuvant chemotherapy.