Table A2.

Description of the radiomics features used in the proposed radiomics_clinical model for recurrence-free survival prediction.

Class	Radiomics Feature	Definition
First order: First order statistics describe the distribution of voxel intensities within the image region defined by the mask through commonly used and basic metrics.	Original_firstorder_Range	The range of first order value in the ROI
	Original_firstorder_10Percentile	The 10th percentile of first order value.
	Original_firstorder_ TotalEnergy	Total Energy is the value of the Energy feature scaled by the volume of the voxel in cubic mm
	Original_firstorder_ InterquartileRange	The different value 25th and 75th percentile of the first order value.
GLSZM: A gray level size Zone (GLSZM) quantifies gray level zones in an image	original_glszm_ grayLevelNonUniformity	GrayLevelNonUniformity measures the variability of gray-level intensity values in the GLSZM array.
	Original_glszm_ LargeAreaLowGrayLevelEmphasis	It measures the proportion in the image of the joint distribution of larger size zones with lower gray level values
	Original_glszm_ SizeZoneNonUniformity	It measures the variability of size zone volumes throughout the GLSZM array, with a lower value indicating more homogeneity among zone size volumes in the GLSZM array.
	Original_glszm_ ZoneEntropy	It measures the uncertainty/randomness in the distribution of zone sizes and GLSZM levels
GLRLM: A gray level run length matrix (GLRLM) quantifies gray level runs, which are defined as the length in number of pixels, of consecutive pixels that have the same gray level value.	Original_glrlm_ GrayLevelNonUniformity	It measures the similarity of gray level intensity values in the GLRLM array.
	Original_glrlm_ RunLengthNonUniformity	It measures the similarity of run lengths throughout the GLRLM array, with a lower value indicating more homogeneity among run lengths in the GLRLM array
GLDM: A gray level dependence matrix (GLDM) quantifies gray level dependencies in an image	Original_gldm_ SmallDependenceEmphasis	A measure of the distribution of large dependencies, with a greater value indicative of larger dependence and more homogeneous textures.