Figure 4.

Schematic demonstrating the amino acid sequence of human preproinsulin with annotations of the location of insulin mutations impacting trafficking, processing, and IR interactions. Displayed domains: the amino-terminal (N-ter) signal peptide (red), B-chain (yellow), C-peptide (blue), and the carboxy-terminal (C-ter) A-chain (green). White residues are those which are cleaved during the conversion of proinsulin to insulin. Mutations resulting in stop codons and deletions are seen in red.