Table 3.
Prognostic analysis of ORR (a) and DCR (b) in patients who received immune checkpoint inhibitor therapy.
| (a) Overall Response Rate | ||||||
|---|---|---|---|---|---|---|
| Univariate | ||||||
| Odds Ratio | 95% CI | p-Value | ||||
| Age (<70 or >70) | 0.997 | 0.458–2.17 | 0.9940 | |||
| BMI (Cutoff: 20) | 0.527 | 0.211–1.32 | 0.1720 | |||
| Alb (Cutoff:4.1) | 0.676 | 0.289–1.58 | 0.3650 | |||
| CRP (Cutoff:0.89) | 1.35 | 0.582–3.11 | 0.4880 | |||
| PLR (Cutoff: 397) | 0.736 | 0.337–1.61 | 0.4410 | |||
| NLR (Cutoff: 6.7) | 0.732 | 0.336–1.6 | 0.4330 | |||
| LMR (cutoff: 1.88) | 0.892 | 0.386–2.06 | 0.7890 | |||
| SII (Cutoff: 107.5) | 1.44 | 0.518–4.02 | 0.4830 | |||
| CAR (Cutoff: 0.14) | 0.623 | 0.272–1.43 | 0.2640 | |||
| CONUT (Cutoff: 3) | 0.78 | 0.26–2.34 | 0.6570 | |||
| PNI (Cutoff: 37.7) | 1.72 | 0.781–3.78 | 0.1780 | |||
| PI (Cutoff: 0) | 2.01 | 0.817–4.92 | 0.1290 | |||
| GPS (Cutoff: 0) | 0.627 | 0.277–1.42 | 0.2630 | |||
| (b) Disease control rate | ||||||
| Univariate | Multivariate | |||||
| Odds ratio | 95% CI | p-value | Odds ratio | 95% CI | p-value | |
| Age (<70 or >70) | 0.452 | 0.179–1.14 | 0.0925 | 0.391 | 0.145–1.06 | 0.651 |
| BMI (Cutoff: 20) | 0.393 | 0.149–1.04 | 0.0598 | 1.82 | 0.682–4.86 | 0.232 |
| Alb (Cutoff:4.1) | 0.487 | 0.192–1.24 | 0.1300 | |||
| CRP (Cutoff:0.89) | 2.4 | 0.952–6.05 | 0.0635 | |||
| PLR (Cutoff: 397) | 0.365 | 0.144–0.923 | 0.0332 | 0.397 | 0.117–1.41 | 0.157 |
| NLR (Cutoff: 6.7) | 0.626 | 0.255–1.54 | 0.3070 | |||
| LMR (cutoff: 1.88) | 0.521 | 0.206–1.31 | 0.1670 | |||
| SII (Cutoff: 107.5) | 2.93 | 1.01–8.52 | 0.0478 | 0.613 | 0.186–2.02 | 0.420 |
| CAR (Cutoff: 0.14) | 0.382 | 0.152–0.957 | 0.0399 | 0.619 | 0221–1.74 | 0.360 |
| CONUT (Cutoff: 3) | 0.448 | 0.142–1.41 | 0.1700 | |||
| PNI (Cutoff: 37.7) | 2.09 | 0.847–5.16 | 0.1100 | |||
| PI (Cutoff: 0) | 2.54 | 0.788–8.18 | 0.1190 | |||
| GPS (Cutoff: 0) | 0.434 | 0.174–1.08 | 0.0726 |
ORR, objective response rate; DCR, disease response rate; PLR, platelet to lymphocyte ratio; NLR, neutrophil to lymphocyte ratio; LMR, lymphocyte to monocyte ratio; SII, systemic immune-inflammation index; CAR, CRP to Alb ratio; CONUT, controlling nutritional status; PNI, prognostic nutrition index; PI, predictive index; GPS, Glasgow prognostic score; BMI, body mass index; Alb, albumin; CRP, C-reactive protein. Bold indicates statistically significant p-values.