Table 3.
Genetic variants with allele frequencies less than 0.0001 (MAF < 0.0001) according to gnomAD in tooth-related genes in patients with FREM2 variants with mesiodens or isolated supernumerary teeth.
| Tooth-Related Genes | Patient 1 3212 Mesiodens |
Patient 2 095 Mesiodens (Double) |
Patient 3 2952 Mesiodens (Double) |
Patient 4 3346 Mesiodens |
Patient 5 2775 Supernumerary Premolars |
Patient 6 3036 Mesiodens and Tooth Agenesis, and Taurodontism |
Patient 7 3099 Supernumerary Premolars, Oral tori, Root Maldevelopment |
Patient 8 3262 Multiple Supernumerary Teeth and Multiple Odontomas |
|---|---|---|---|---|---|---|---|---|
| WNT10A | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| WNT10B | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| PAX9 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| AXIN2 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| MSX1 | Not found | Not found | Not found |
MSX1 Variant NM_002448.3:c.461C>T NP_002439.2:p.Pro154Leu rs545651715 chr4:g.4862087C>T MAF = 0.00003574 |
Not found | Not found | Not found | Not found |
| LRP4 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| LRP5 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| LRP6 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| WLS | Not found | Not found | Not found | Not found |
WLS Variant NM_001002292.3:c.130A>T NP_001002292.3:p.Met44Leu chr1:g.68659881T>A rs368633951 MAF: 0.00003891 |
Not found | Not found | Not found |
| DKK1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| BMP4 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| GREM2 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| TFAP2B | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| TSPEAR | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| EDA | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| EDAR | Not found | Not found | Not found | Not found | Not found | Not found | Not found | |
| EDARADD | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| PITX2 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| EVC | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| EVC2 |
EVC2 Variant NM_001166136.2:c.33dup NP_001159608.1:p.Lys12Ter chr4:g.5699332dup No rs number Not reported in gnomAD |
Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| COL1A2 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| ANTXR1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| FGF10 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| SMOC2 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| KREMEN1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| KDF1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| ATF1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| DUSP10 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| CASC8 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| RUNX2 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| TRPS1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| C2CD3 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| NHS | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| MID1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| CREBBP | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| EP300 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| BCOR | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| WNT5A | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| DVL1 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| DVL3 | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |
| IL11RA | Not found | Not found | Not found | Not found | Not found | Not found | Not found | Not found |