Table 2.

Univariable and multivariable analysis of factors for recurrence-free survival and overall survival in patients with non-metastatic and resected NF-PanNETs.

Factors	Recurrence-Free Survival				Overall Survival
	Univariable		Multivariable		Univariable		Multivariable
	HR (95% CI)	p-Value	HR (95% CI)	p-Value	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Gender: male vs. female	0.863 (0.547–1.360)	0.525			1.249 (0.366–4.268)	0.723
Age: <55 vs. ≥55 years	1.283 (0.813–2.025)	0.285			1.401 (0.408–4.814)	0.593
Tumor size: <2.5 vs. ≥2.5 cm	6.120 (3.142–11.919)	<0.001	4.975 (2.538–9.752)	<0.001	7.662 (0.974–60.291)	0.053
Tumor location: head vs. neck/body/tail	1.069 (0. 657–1.738)	0.789			1.281 (0.340–4.831)	0.714
Lymph node positive: no vs. yes	4.448 (2.745–7.206)	<0.001	2.818 (1.628–4.879)	<0.001	5.284 (1.605–17.398)	0.006
Perineural invasion: no vs. yes	2.608 (1.527–4.455)	0.001			3.446 (0.861–13.782)	0.080
Microvascular invasion: no vs. yes	3.317 (2.058–5.345)	<0.001			4.958 (1.425–17.250)	0.012	4.395 (1.215–15.905)	0.024
Margin status: R0 vs. R1	4.963 (1.997–12.331)	0.001			4.794 (0.606–37.939)	0.138
Adjuvant treatment: no vs. yes	3.643 (2.178–6.093)	<0.001	1.840 (1.004–3.373)	0.048	4.587 (1.338–15.730)	0.015
WHO classification: G1/G2 vs. G3	12.357 (5.810–26.280)	<0.001	6.904 (2.994–15.916)	<0.001	16.665 (4.225–65.732)	<0.001	7.718 (1.543–38.602)	0.013

HR: hazard ratio; CI: confidence interval; WHO: World Health Organization.