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. 2023 Mar 29;12(7):1040. doi: 10.3390/cells12071040

Figure 6.

Figure 6

Effect of PF-475 treatment on behavioral function. The sucrose preference test showed that mTBI significantly reduced the percentage of sucrose preference, while PF-475 (2.5 and 5 mg/kg) restored it (A). The forced swim test demonstrated that the increased immobility time induced by mTBI in mice was decreased after treatment with PF-475 at doses of 2.5 and 5 mg/kg (B). The elevated plus maze test showed that PF-475 treatment (2.5 and 5 mg/kg) reduced depression symptoms after mTBI induction, reducing the number of entries and time spent in closed arms (D,F); PF-475 increased the number of entries and time spent in open arms (C,E) and reduced the time spent at center (G). Data was expressed as SD from 10 mice for each group. Two-way ANOVA test. *** p < 0.001 vs. non mTBI; ### p< 0.001 vs. mTBI.