Table 6.

Molecular signatures of thyroid cancer in pediatric and adult; SNV: single nucleotide variation; pTERT: TERT promoter [10].

Mutation Type	Molecular Landscape	Pediatric	Adult
PTC
SNV	BRAF V600E	<70%	30–90%
	pTERT	<5%	5–25%
	DICER1	5–10%	<5%
	HRAS, KRAS, NRAS	<10%	<35%
Fusion	RET	20–80%	5–35%
	PAX8-PPARG	<5%	<5%
	NTRK	<20%	<5%
	BRAF	<20%	<3%
	ALK	<10%	<3%
FTC
SNV	HRAS, KRAS, NRAS	<50%	10–60%
Fusion	DICER1	<25%	1%
	PTEN	<25%	<1%
	PAX8-PPARG	<20%	35–50%