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. 2023 Mar 28;24(7):6322. doi: 10.3390/ijms24076322

Figure 3.

Figure 3

IL-10 mediated CXCL13 expression in FMDV-infected mice. (A) CXCL13 concentrations in sera from mock mice, infected mice with anti-IL-10R antibody, and infected mice with isotype antibody were measured by ELISA. (B) CXCL13 concentrations in sera from mock mice, wild-type mice infected with FMDV, IL-10-/- mice, and IL-10-/- mice infected with FMDV were measured by ELISA. The mRNA expressions of CXCL13 were detected in the heart (C) and spleen (D) of mock mice, infected-mice with anti-IL-10R antibody, and infected-mice with isotype antibody at 48 hpi. The mRNA expressions of CXCL13 were detected in the heart (E) and spleen (F) of mock mice, wild-type mice infected with FMDV, IL-10-/- mice, and IL-10-/- mice infected with FMDV at 48 hpi. Significance was detected using unpaired t test. **, p ≤ 0.01; ***, p ≤ 0.001; ****, p ≤ 0.0001.