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Cytotoxicity of ixabepilone against 21 tumor cell lines.
| Cell Line | Ixabepilone IC50 (nM) | Cell Line | Ixabepilone IC50 (nM) | Cell Line | Ixabepilone IC50 (nM) |
|---|---|---|---|---|---|
| A2780/DDP-S | 2.8 | A2780/DDP-R | 1.8 | A2780/TAX-S | 2.6 |
| A2780/TAX-R | 4.9 | OVCAR-3 | 1.8 | MCF-7 | 2.7 |
| SKBR3 | 2.3 | LNCAP | 1.5 | PC3 | 4.6 |
| HCT116 | 2.6 | HCT116/VM46 | 24.5 | HCT116/VP35 | 2.0 |
| LS174T | 5.8 | MIP | 24.8 | A549 | 5.2 |
| LX-1 | 3.1 | A431 | 1.4 | CCRF-CEM | 6.0 |
| K562 | 2.9 | M109 | 2.9 | MLF | 34.5 |
Median IC50: 2.9 nM.
