Fig. 2. Design and characterization of a green light activatable oxaliplatin(iv) prodrug. (a) Synthetic route to the RB-Pt prodrug. (b) UV-vis absorption spectra of RB and RB-Pt. (c) ESI-MS results of RB-Pt under irradiation of green light. The m/z range is 700–1600. [RB-HA-H]−, calculated 1086.81, found 1086.55; [RB-Pt-H]−, calculated 1500.10, found 1499.61. (d) The leading edge orbital of the ground state (S0) and the highest individually occupied molecular orbital of the lowest excited triplet state (T1) of RB and RB-Pt, and the fitted excited state features of the corresponding theoretically predicted energy gap. (e) Proposed mechanism of photo-induced reduction of RB-Pt.
