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. 2023 Mar 23;24(7):6102. doi: 10.3390/ijms24076102

Figure 3.

Figure 3

Exosome crosstalk in the tumor microenvironment (TME) of diffuse large B-cell lymphoma (DLBCL). DLBCL cells secrete microRNA-21 (miR-21)-enriched exosomes into the TME to tumor-associated macrophages (TAM), which internalize these tumor-derived exosomes and promote macrophage M2 polarization, favoring tumor growth and progression. TAMs also secrete miR-21-enriched exosomes to DLBCL cells further promoting lymphomagenesis. Bovine milk-derived exosomes (MDEs) also transport miR-21 to recipient cells that may reach TAMs and/or DLBCL cells further augmenting miR-21-mediated oncogenic signaling.