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. 2023 Mar 27;24(7):6295. doi: 10.3390/ijms24076295

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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DAPT regulates MP-induced cell differentiation by inhibiting the Notch pathway. (A) Cell viability under different DAPT concentrations in 24 h. (B) The mRNA level of the Notch pathway exposed to the MP and DAPT in BMSCs. (C) The protein expression of p-Notch1, Notch1, Notch2 and RBPJ was detected by western blotting analysis treated with MP and DAPT. (D–E) The expression levels of Col2a1 and Aggrecan in BMSCs were determined by qRT-PCR and western blot. (F) Effects of DAPT on the expression levels of BMP2, Runx2, MMP9 and MMP13 in BMSCs tested by qRT-PCR. (G) The protein levels of BMP2 and MMP13 in BMSCs. * p < 0.05 were considered statistically significant and ** p < 0.01 means extremely significant.