Scheme 1. Synthesis of: (a) [2]rotaxane 2; and (b) macrocycle 4. Reaction conditions: (i) N¹,N³-bis[4-(aminomethyl)benzyl]isophthalamide, 5-bromoisophthaloyl dichloride, Et₃N, CHCl₃, 25 °C, 4 h; (ii) bis(pinacolato)diboron, Pd(dppf)Cl₂ (5 mol%), AcOK, dioxane, 90 °C, 24 h.