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. 2023 Mar 23;24(7):6052. doi: 10.3390/ijms24076052

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of Doxorubicin treatment on heart function and blood parameters. (A) Top Exemplary M-mode echocardiograms from parasternal short axis views of the mouse heart of both the control (CTRL) and Doxorubicin (DOX) group before (d0) and after treatment (d6). Bottom Comparison of heart rate in isoflurane narcosis, as well as left ventricular ejection fraction (EF) and fractional shortening (FS) of CTRL and DOX treated animals (n = 5–8, ANOVA with Bonferroni post-hoc test, *: p < 0.05). (B) Top Levels of creatine kinase (CK) and highly sensitive cardiac troponin I (hscTnI) from control and doxorubicin treated animals at day 6 after beginning of experiment (n = 5–9, Student’s t-test with Welch correction, *: p < 0.05, ***: p < 0.001). Bottom Number of leucocytes, erythrocytes and thrombocytes present in the blood of CTRL and DOX groups at day 6 after injection (n = 5–9, Mann–Whitney test, ***: p < 0.001). ns: not significant.

Effects of Doxorubicin treatment on heart function and blood parameters. (A) Top Exemplary M-mode echocardiograms from parasternal short axis views of the mouse heart of both the control (CTRL) and Doxorubicin (DOX) group before (d0) and after treatment (d6). Bottom Comparison of heart rate in isoflurane narcosis, as well as left ventricular ejection fraction (EF) and fractional shortening (FS) of CTRL and DOX treated animals (n = 5–8, ANOVA with Bonferroni post-hoc test, *: p < 0.05). (B) Top Levels of creatine kinase (CK) and highly sensitive cardiac troponin I (hscTnI) from control and doxorubicin treated animals at day 6 after beginning of experiment (n = 5–9, Student’s t-test with Welch correction, *: p < 0.05, ***: p < 0.001). Bottom Number of leucocytes, erythrocytes and thrombocytes present in the blood of CTRL and DOX groups at day 6 after injection (n = 5–9, Mann–Whitney test, ***: p < 0.001). ns: not significant.