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. 2023 Mar 23;24(7):6029. doi: 10.3390/ijms24076029

Table 1.

Meta-analysis of the discovery cohort with GWAS data from the UKBiobank and FinnGen projects.

Gene_SNP ID Discovery Cohort
(n = 5482)		 UKBiobank
(n = 403,268)		 FinnGen
(n = 249,609)		 Meta-Analysis
(n = 658,359)
OR (95% CI) ∂ p OR (95% CI) p OR (95% CI) p OR (95% CI) p PHet
ADCY3_rs11676272 1.04 (1.13–0.95) 0.36 1.05 (0.93–1.17) 0.44 1.09 (0.99–1.19) 0.084 1.06 (1.00–1.11) 0.046 0.47
0.36
ADPGK_rs7164727 1.01 (1.10–0.91) 0.86 0.98 (0.87–1.10) 0.71 1.07 (0.97–1.18) 0.20 0.98 (0.92–1.04) 0.63
AKAP6_rs17522122 0.94 (1.06–0.84) 0.31 1.08 (0.96–1.21) 0.22 1.02 (0.93–1.12) 0.66 1.01 (0.95–1.08) 0.70 0.22
0.97
BDNF_rs6265 1.00 (1.36–0.74) 1.00 0.97 (0.83–1.12) 0.65 0.97 (0.86–1.10) 0.63 0.97 (0.88–1.07) 0.51
DNASE1_rs1053874 1.08 (1.20–0.96) 0.19 1.04 (0.92–1.18) 0.52 0.91 (0.82–1.00) 0.056 1.00 (0.93–1.06) 0.88 0.12
0.73
FAIM2_rs7138803 0.99 (1.08–0.91) 0.85 1.01 (0.90–1.13) 0.90 0.95 (0.86–1.04) 0.28 0.98 (0.93–1.04) 0.48
FLT3_rs1933437 0.94 (1.04–0.83) 0.27 0.98 (0.85–1.09) 0.69 0.91 (0.81–1.01) 0.090 0.94 (0.87–1.00) 0.054 0.77
0.34
0.008
FTO_rs1421085 0.95 (1.04–0.85) 0.33 1.10 (0.97–1.24) 0.14 1.01 (0.93–1.11) 0.77 1.01 (0.95–1.06) 0.78
FTO_rs7190492 1.06 (1.16–0.98) 0.15 0.93 (0.79–1.05) 0.27 1.01 (0.92–1.10) 0.79 1.02 (0.96–1.08) 0.54
GNPDA2_rs10938397 1.05 (1.14–0.96) 0.26 1.01 (0.90–1.12) 0.93 1.01 (0.93–1.10) 0.80 1.03 (0.97–1.08) 0.37 0.62
0.69
GPRC5B_rs12444979 1.13 (1.62–0.79) 0.51 0.96 (0.82–1.13) 0.65 1.03 (0.90–1.17) 0.70 1.01 (0.91–1.12) 0.85
ITH4_rs4687657 1.04 (1.15–0.94) 0.48 0.97 (0.85–1.10) 0.61 1.07 (0.96–1.18) 0.22 1.03 (0.97–1.10) 0.33 0.72
0.93
KCTD15_rs11084753 1.04 (1.17–0.92) 0.53 0.99 (0.87–1.10) 0.91 0.99 (0.89–1.08) 0.84 1.00 (0.94–1.07) 0.88
LMOD1_rs2820312 0.99 (1.09–0.91) 0.89 0.96 (0.85–1.08) 0.49 0.96 (0.87–1.06) 0.40 0.97 (0.92–1.03) 0.36 0.94
0.61
0.99
LOC400652_rs17782313 1.06 (1.15–0.96) 0.23 1.01 (0.89–1.15) 0.88 1.03 (0.92–1.16) 0.57 1.04 (0.97–1.10) 0.24
MAF_rs1424233 0.99 (1.07–0.92) 0.83 1.01 (0.89–1.11) 0.89 1.00 (0.91–1.08) 0.99 1.00 (0.95–1.05) 0.95
MC4R_rs17700633 1.04 (1.15–0.94) 0.43 0.99 (0.88–1.12) 0.92 0.91 (0.82–1.02) 0.096 0.98 (0.92–1.05) 0.60 0.37
0.92
0.43
MST1R_rs2230590 0.95 (1.04–0.85) 0.26 1.00 (0.88–1.14) 0.98 0.97 (0.89–1.07) 0.57 0.97 (0.91–1.03) 0.30
MTCH2_rs3817334 0.89 (0.99–0.81) 0.024 0.98 (0.88–1.10) 0.78 0.99 (0.91–1.08) 0.91 0.95 (0.90–1.01) 0.12
NEGR1_rs2815752 0.95 (1.04–0.86) 0.32 1.03 (0.91–1.14) 0.63 1.05 (0.96–1.14) 0.29 1.01 (0.95–1.06) 0.83 0.16
NPC1_rs1805081 1.16 (1.35–0.91) 0.19 0.93 (0.83–1.05) 0.24 1.02 (0.93–1.11) 0.71 1.00 (0.93–1.07) 0.96 0.20
0.88
NT5C2_rs11191580 0.98 (1.14–0.79) 0.81 0.97 (0.78–1.19) 0.77 1.03 (0.88–1.21) 0.73 1.00 (0.89–1.09) 0.94
PCSK1_rs6235 1.01 (1.11–0.91) 0.92 1.10 (0.98–1.21) 0.099 1.05 (0.95–1.14) 0.35 1.05 (0.98–1.12) 0.16 0.36
POC5_rs2112347 1.09 (1.17–1.00) 0.055 1.07 (0.95–1.21) 0.28 1.07 (0.98–1.18) 0.13 1.08 (1.02–1.13) 0.0083 0.96
SEC16B_rs543874 1.03 (1.14–0.90) 0.63 0.93 (0.81–1.08) 0.35 1.04 (0.92–1.16) 0.56 1.01 (0.93–1.08) 0.87 0.67
SH2B1_rs7359397 0.94 (1.06–0.84) 0.33 0.97 (0.86–1.09) 0.63 1.12 (1.02–1.23) 0.017 1.03 (0.96–1.09) 0.41 0.043
0.19
STK33_rs10769908 1.00 (1.10–0.88) 0.96 0.91 (0.77–1.03) 0.14 1.06 (0.97–1.15) 0.17 1.00 (0.94–1.06) 0.91
TFAP2B_rs2206277 1.03 (1.16–0.91) 0.65 1.13 (0.96–1.32) 0.14 1.00 (0.90–1.10) 0.97 1.04 (0.96–1.11) 0.34 0.17
TMEM18_rs6548238 0.94 (1.06–0.83) 0.30 1.05 (0.89–1.18) 0.53 0.99 (0.86–1.10) 0.84 0.98 (0.91–1.06) 0.65 0.73
TRAF3_rs10133111 1.05 (1.19–0.92) 0.46 1.00 (0.87–1.16) 0.97 1.10 (0.99–1.23) 0.080 1.06 (0.99–1.15) 0.11 0.68
UHRF1BP1_rs11755393 0.99 (1.14–0.82) 0.90 1.02 (0.90–1.14) 0.79 0.97 (0.88–1.07) 0.53 0.99 (0.91–1.06) 0.72 0.95
ZZZ3_rs17381664 0.97 (1.06–0.87) 0.51 0.95 (0.84–1.07) 0.39 – – 0.96 (0.88–1.03) 0.29 0.91

Abbreviatures: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval. A fixed effect model was assumed for the meta-analysis of all cohorts. ∂ Association estimates were adjusted for age and sex and were calculated according to log-additive model of inheritance. p ≤ 0.05 in bold.