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. 2023 Mar 24;24(7):6132. doi: 10.3390/ijms24076132

Figure 4.

Figure 4

Expression of differentiation markers in NHKs after NF- and HTSF-exosome treatment. The mRNA and protein expression of KRT1 (A,B) in NHKs increased significantly at 24 and 48 h after treatment with 100 μg/mL NF- or HTSF-exosomes, compared with that in the control cells; mRNA and protein expression of KRT1 significantly increased after treatment with HTSF-exosomes compared with NF-exosomes. The mRNA and protein expression of KRT10 (C,D) in NHKs increased and was unchanged at 24 h and 48 h after treatment with 100 μg/mL NF-exosomes, respectively; however, mRNA and protein expression of KRT10 increased at 24 h and 48 h after treatment with 100 μg/mL HTSF-exosomes, compared with that in control cells. * p < 0.05 for NF- or HTSF-exosome-treated cells versus the corresponding matched control cells. † p < 0.05 for HTSF-exosome-treated cells versus NF-exosome-treated cells. Data represent the mean ± SD; n = 4. Ct, DPBS-treated control cells; NHK, normal human keratinocytes; NF, normal tissue-derived fibroblasts; HTSF, hypertrophic scar tissue-derived fibroblasts.