Skip to main content
. 2023 Mar 24;24(7):6132. doi: 10.3390/ijms24076132

Figure 7.

Figure 7

Expression of the regulators of the cyclin-dependent kinase inhibitor in NHKs after NF-and HTSF-exosome treatment. The mRNA and protein expression of C-MYC (A,B) in NHKs increased significantly at 24 and 48 h after treatment with 100 μg/mL HTSF-exosomes but remained unchanged after treatment with NF-exosomes, compared with that in the control cells. The mRNA and protein expression of Notch1 (C,D) and PKCη (E,F) increased significantly at 24 and 48 h after treatment with 100 μg/mL NF- and HTSF-exosomes, compared with that in the control cells. The mRNA and protein expression of Notch1 and PKCη increased to a greater degree with HTSF-exosome treatment than with NF-exosome treatment. * p < 0.05 for NF- or HTSF- exosome-treated cells versus the corresponding matched control cells. † p < 0.05 for HTSF-exosome-treated cells versus NF-exosome-treated cells. Data represent the mean ± SD; n = 4. Ct, DPBS-treated control cells; NHK, normal human keratinocytes; NF, normal tissue-derived fibroblasts; HTSF, hypertrophic scar tissue-derived fibroblasts.