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The 2D (A,B) and 3D (a,b) structures of LAT1 inhibitor SKN series and LAT3 inhibitor ESK series. (Aa) SKN series and JPH203 have similar molecular structures. (B,b) The ESK series shows a different molecular structure from LAT1 inhibitors such as T3, JPH203, and SKNs. ESK242 can inhibit both LAT1 and LAT3.
