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. 2023 Mar 25;24(7):6234. doi: 10.3390/ijms24076234

Figure 2.

Figure 2

Effects of thiosulfinate-enriched Allium sativum extract (TASE) in LPS response of monocytes from both HV and septic patients. (A) Monocytes from HV (n = 15) and septic patients (n = 7) were stimulated with 10 ng/mL for 16 h in the presence or not of 3 µg/mL of TASE and labeled with cytometry antibodies. Fold induction of HLA-DR mean intensities of fluorescence against basal on gated CD14+ monocytes determined by flow cytometry are shown. (B–D) Monocytes from HV (n = 15) and septic patients (n = 7) were stimulated with 10 ng/mL of LPS for 16 h in combination or not with 3 µg/mL of GE and inflammatory cytokine levels of TNF-α (B), IL-1β (C) and IL-6 (D) were measured. Concentrations are shown. KW, Kruskal–Wallis statistic; #, p < 0.05; ##, p < 0.01; ###, p < 0.001 in Dunn’ post hoc test. *, p < 0.05 in paired t test. White dots represent individual HV values and red dots individual sepsis values. Left panels show paired analysis of individual values and bars express mean ± SD.