Skip to main content
. 2023 Mar 28;24(7):6330. doi: 10.3390/ijms24076330

Figure 5.

Figure 5

SUL-138 limited the increase in CLP-induced systemic inflammation as evidenced by the normalization of circulating cytokines in mice. Mice treated with SUL-138 (5 mg/kg) were injected s.c. 2 h before induction of CLP, followed by a second dose at 10 h after induction of CLP. Blood samples were drawn 24 h after sepsis induction. (A) Xiphoid temperature was reduced in the CLP group, while xiphoid temperature in the CLP SUL-138 group was not significantly reduced after 24 h. (B) Body weight was unchanged between groups. (C–E) CLP reduced white blood cell counts, hemoglobin levels, and red blood cell counts, which were unaffected by SUL-138. (F,G) CLP increased IL-6 plasma and TNF-α levels, which were precluded by SUL-138. Control (n = 8), sham (n = 8), CLP (n = 8) and CLP SUL-138 (n = 6). Data are represented as mean ± SEM, * p < 0.05. CLP, cecal ligation and puncture.