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. 2023 Mar 29;24(7):6443. doi: 10.3390/ijms24076443

Figure 5.

Figure 5

Heart weight (HW) and body weight (BW) as well as HW/BW ratios of mice. Female mice had reduced heart weight (A), *** p < 0.001 male vs. female and ### p < 0.001 WT male vs. KO female, Student’s t-test; two-way ANOVA: sex p < 0.001. Female mice had reduced body weight (B) compared to male mice, *** p < 0.001 male vs. female, ### p < 0.001 WT male vs. KO female, Student’s t-test; two-way ANOVA: sex p < 0.001. HW/BW ratios (C) were similar in WT males and females as well as in male cardiomyocyte-specific knockout (KO) mice, while in female KO mice HW/BW ratio was reduced, * p < 0.05 KO male vs. KO female and ## p < 0.01 WT male vs. KO female, Student’s t-test. Two-way ANOVA: sex * genotype p = 0.088. (WT male n = 14; WT female n = 9; KO male n = 11; KO female n = 11). Data are represented as box plots expressing median, 25% and 75 % quartiles, upper and lower whisker and outliers (○,Inline graphic).