Table 2.
Genes affected by alternative polyadenylation in osteoarthritic chondrocytes with corrected p-values for distal and proximal sites set to <0.1.
| Gene Locus | Strand | ENSEMBL Gene_id | Gene Symbol | Proximal/Distal polyA Sites | Proximal/ Distal Feature |
Proximal log2fc | Distal log2fc | Proximal Adjusted p-Value | Distal Adjusted p-Value |
|---|---|---|---|---|---|---|---|---|---|
| chr11:118482737–118526831 | + | ENSG00000118058 | KMT2A | 118523915, 118526830 | utr3/utr3 | 2.06168 | −1.67404 | 0.01625 | 0.00558 |
| chr11:10812073–10858795 | - | ENSG00000236287 | ZBED5 | 10852797, 10852747 | utr3/utr3 | 2.29148 | −2.94875 | 0.01812 | 0.0418 |
| chr9:97501179–97601742 | + | ENSG00000136842 | TMOD1 | 97600155, 97601252 | utr3/utr3 | 1.51617 | −1.24927 | 0.02117 | 0.01554 |
| chr21:15730024–15880068 | + | ENSG00000155313 | USP25 | 15878905, 15880062 | utr3/utr3 | −1.52865 | 3.44074 | 0.00356 | 0.054 |
| chr11:65422773–65445539 | + | ENSG00000245532 | NEAT1 | 65426414, 65426524 | exon/exon | −0.82173 | 1.04492 | 0.06951 | 0.08359 |
| chr19:45349836–45370917 | - | ENSG00000104884 | ERCC2 | 45351594, 45349837 | utr3/utr3 | −1.70459 | 2.32543 | 0.0418 | 0.07641 |
| chr11:111540279–111561744 | + | ENSG00000204381 | LAYN | 111560953, 111561510 | utr3/utr3 | −1.46532 | 2.04648 | 0.06024 | 0.09604 |
| chr5:136132844–136188746 | + | ENSG00000113658 | SMAD5 | 136179501, 136182732 | utr3/utr3 | −3.68803 | 1.67826 | 0.08576 | 0.00919 |
| chr9:129634603–129642168 | - | ENSG00000148331 | ASB6 | 129636893, 129634604 | utr3/utr3 | −1.45783 | 1.29424 | 0.09604 | 0.08311 |
| chr12:51186935–51217707 | - | ENSG00000184271 | POU6F1 | 51189184, 51186936 | utr3/utr3 | 1.70409 | −1.32788 | 0.08359 | 0.0527 |
| chr8:23528955–23575462 | + | ENSG00000147454 | SLC25A37 | 23572547, 23575460 | utr3/utr3 | 0.68296 | −1.24319 | 0.06512 | 0.07641 |
| chr2:44316280–44361861 | - | ENSG00000138078 | PREPL | 44318763, 44317605 | utr3/intron | −1.54952 | 2.27364 | 0.01646 | 0.04608 |
| chr5:38845857–38945595 | + | ENSG00000145623 | OSMR | 38886653, 38935628 | intron/utr3 | 0.7451 | −1.81506 | 0.03228 | 0.00233 |
| chr5:132556018–132646348 | + | ENSG00000113522 | RAD50 | 132616045, 132642473 | utr3/utr3 | 3.07214 | −5.49643 | 0.00683 | 0.04908 |
| chr3:48241099–48299252 | + | ENSG00000164048 | ZNF589 | 48270986, 48273225 | utr3/intron | −0.70227 | 0.75939 | 0.04908 | 0.05682 |
| chr7:77798791–77957502 | + | ENSG00000006576 | PHTF2 | 77940457, 77957223 | utr3/utr3 | 3.12642 | −2.27133 | 0.05189 | 0.01812 |
| chr2:85751343–85791382 | + | ENSG00000168874 | ATOH8 | 85775209, 85791376 | exon/utr3 | 3.02271 | −3.80491 | 0.01812 | 0.05189 |
| chr6:85449583–85495790 | + | ENSG00000135318 | NT5E | 85452154, 85495783 | intron/utr3 | 1.14747 | −1.70338 | 0.04908 | 0.0273 |
| chrX:8528873–8732136 | - | ENSG00000011201 | ANOS1 | 8536187, 8528874 | intron/utr3 | 3.04985 | −3.07918 | 0.00008 | 0.00008 |
| chr12:19404044–19720800 | + | ENSG00000139154 | AEBP2 | 19441779, 19520222 | intron/utr3 | 3.11654 | −1.15156 | 0.09497 | 0.00558 |