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. 2023 Apr 6;24(7):6816. doi: 10.3390/ijms24076816

Figure 8.

Figure 8

Synergistic effect of KPT-330 with AZA on apoptosis in primary cells from the AML patients. (A) Effect of drug treatment (DMSO, KPT-330, AZA, and combo) on apoptosis in primary cells from AML patient 1 (PT1). (B) Effect of drug treatment (DMSO, KPT-330, AZA, and combo) on apoptosis in primary cells from AML patient 2 (PT2). (C) Quantitative bar chart for PT1 and PT2. (D) Effect of drug treatment (DMSO, KPT-330, AZA, and combo) on apoptosis-related protein (BCL2 and BAX) in primary cells from AML PT1 and PT2. (E) Effect of drug treatment (DMSO, KPT-330, AZA, and combo) on XPO1, elF4, and c-MYC in primary cells from AML patient PT1 and PT2. *** p < 0.001.