Table 2.

Main research needed before implementing therapy targeted to endotoxemia in patients with acute heart failure and/or cardiogenic shock according to the authors.

Thematic	Objective	Type of Research
Mechanism of translocation	Determining the route for endotoxin translocation in patients with ischemia-reperfusion injury	Experimental
Patient selection	Determining a phenotype/group of patients that would benefit from endotoxin removal	Observational cohort
Detoxification	Evaluating the different therapeutic targeted to endotoxemia available (in the population of interest).	Randomized controlled trial