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. 2023 Mar 31;24(7):6557. doi: 10.3390/ijms24076557

Figure 1.

Figure 1

Aerobic metabolism and mitochondria structure in lymphoblasts mutated for the FANC-A gene. Oximetric traces of FAcorr (A) and FA (B) lymphoblasts. Arrows indicate the respiratory substrates or inhibitors’ addition. (C) Oxygen consumption rate (OCR). (D) Aerobic ATP synthesis. (E) P/O ratio, representing an OxPhos efficiency marker. (F) Electron transfer between respiratory complexes I and III. (G) Representative electron microscopy imaging of FAcorr and FA lymphoblasts to evaluate the mitochondrial morphology. Black scale bars correspond to 1 µm. Data reported in Panels A–E were obtained using pyruvate/malate or succinate as respiring substrates. Data reported in Panels A–F are reported as mean ± SD, and each panel is representative of at least three independent experiments. Statistical significance was tested opportunely with an unpaired t-test or one-way ANOVA; *, **, and **** represent a significant difference for p < 0.05, 0.01, or 0.0001, respectively, between FA and FAcorr cells.