Table 1.
Modification of the studied cytogenetic and molecular genetic indicators in endothelial cells in response to atorvastatin treatment compared to the positive control (m ± IQR).
| Indicator | HCAEC | HITAEC | ||||
|---|---|---|---|---|---|---|
| MMC+Atv | MMC/Atv | Positive Control | MMC+Atv | MMC/Atv | Positive Control | |
| MN frequency, % | 4.70 ± 0.80 | 3.05 ± 1.40 | 3.80 ± 1.35 | 3.35 ± 1.75 | 3.75 ± 1.30 | 4.65 ± 6.50 |
| NBUDs frequency, % | 3.25 ± 1.05 | 1.95 ± 2.05 | 2.40 ± 1.65 | 3.20 ± 1.10 | 2.35 ± 1.15 | 3.40 ± 0.60 |
| NPBs frequency, % | 4.75 ± 1.85 | 11.3 ± 3.25 | 4.95 ± 1.65 | 1.65 ± 1.85 | 13.1 ± 3.60 | 14.75 ± 1.20 |
| DDB1 expression, a.u. | 0.275 ± 0.018 | 0.346 ± 0.012 | 0.138 ± 0.033 | 0.103 ± 0.003 | 0.107 ± 0.013 | 0.152 ± 0.063 |
| ERCC4 expression, a.u. | 0.032 ± 0.002 | 0.037 ± 0.003 | 0.016 ± 0.005 | 0.014 ± 0.001 | 0.016 ± 0.001 | 0.014 ± 0.006 |
| ERCC5 expression, a.u. | 0.053 ± 0.003 | 0.069 ± 0.006 | 0.026 ± 0.003 | 0.027 ± 0.002 | 0.045 ± 0.002 | 0.025 ± 0.007 |
Note: Highlighted in red—upregulated indicators, highlighted in blue—downregulated indicators, highlighted in green—unmodified indicators (in comparison with the positive control).