Figure 4.
Liver inflammatory markers in db/db mice fed control diet or diet with CMS121. Representative blot images (A). Vertical lines indicate non-adjacent lanes from the same blot, and dashed lines adjacent groups. (B–G) Respective quantification of blots: (B) p-NF-κB; (C) IL-1β; (D) IL-18; (E) Caspase 1; (F) Caspase 3 (cleaved/uncleaved), and (G) C-reactive protein (CRP). Data are presented as mean ± SD (n = 6–8), and p-values are indicated for the untreated control db/db mice compared to the CMS121-treated mice. Values were normalized to WT group (dashed line), and data are presented as percentages of WT values. One-way ANOVA was used to detect mean changes, and differences between db/db and db/db + 121 were evaluated by the Holm–Sidak post-hoc test.