Table 1.
Association between genotypes frequencies from the most relevant polymorphisms and AD treatment outcome.
| Relapsed | Resistant (TRD) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No | Yes | OR | CI 95% | p-Value | No | Yes | OR | CI 95% | p-Value | ||||||
| N | % | N | % | N | % | N | % | ||||||||
|
BDNF
rs6265 |
CC | 23 | 51.1 | 9 | 60.0 | 1.0 | Referent | - | 32 | 53.3 | 5 | 29.4 | 1.0 | Referent | - |
| CT | 17 | 37.8 | 5 | 33.3 | 0.752 | [0.213–2.650] | 0.657 | 22 | 36.7 | 11 | 64.7 | 3.200 | [0.975–10.501] | 0.049 | |
| TT | 5 | 11.1 | 1 | 6.7 | 0.511 | [0.052–5.003] | 1.000 * | 6 | 10.0 | 1 | 5.9 | 1.067 | [0.105–10.825] | 1.000 * | |
| T carrier | 22 | 48.9 | 6 | 40.0 | 0.697 | [0.213–2.284] | 0.550 | 28 | 46.7 | 12 | 70.6 | 2.743 | [0.860–8.750] | 0.081 | |
|
PTEN
rs12569998 |
TT | 41 | 91.1 | 14 | 87.5 | 1.0 | Referent | - | 55 | 90.2 | 13 | 68.4 | 1.0 | Referent | - |
| TG | 4 | 8.9 | 2 | 12.5 | 1.464 | [0.241–8.881] | 0.648 * | 6 | 9.8 | 6 | 31.6 | 4.231 | [1.173–15.261] | 0.020 | |
| GG | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| G carrier | 4 | 8.9 | 2 | 12.5 | 1.464 | [0.241–8.881] | 0.648 * | 6 | 9.8 | 6 | 31.6 | 4.231 | [1.173–15.261] | 0.020 | |
|
SYN1
rs1142636 |
AA | 28 | 62.2 | 8 | 50.0 | 1.0 | Referent | - | 35 | 59.0 | 6 | 31.6 | 1.0 | Referent | - |
| AG | 12 | 26.7 | 6 | 37.5 | 1.750 | [0.498–6.145] | 0.380 | 18 | 29.5 | 6 | 31.6 | 2.000 | [0.564–7.087] | 0.278 | |
| GG | 5 | 11.1 | 2 | 12.5 | 1.400 | [0.227–8.626] | 0.656 * | 7 | 11.5 | 7 | 36.8 | 6.000 | [1.543–23.333] | 0.006 | |
| G carrier | 17 | 37.8 | 8 | 50.0 | 1.647 | [0.521–5.204] | 0.393 | 25 | 41.0 | 13 | 68.4 | 3.120 | [1.045–9.314] | 0.037 | |
|
GSK3B
rs6438552 |
AA | 20 | 44.4 | 2 | 12.5 | 1.0 | Referent | - | 22 | 36.1 | 9 | 47.4 | 1.0 | Referent | - |
| AG | 16 | 35.6 | 8 | 50.0 | 5.000 | [0.929–26.913] | 0.074 * | 24 | 39.3 | 8 | 42.1 | 0.815 | [0.267–2.483] | 0.718 | |
| GG | 9 | 20.0 | 6 | 37.5 | 6.667 | [1.121–39.660] | 0.042 * | 15 | 24.6 | 2 | 10.5 | 0.326 | [0.062–1.726] | 0.284 * | |
| G carrier | 27 | 55.6 | 14 | 87.5 | 5.600 | [1.137–27.571] | 0.033 * | 39 | 63.9 | 10 | 52.6 | 0.627 | [0.221–1.775] | 0.377 | |
|
MAPK1
rs6928 |
GG | 18 | 40.0 | 11 | 68.8 | 1.0 | Referent | - | 29 | 47.5 | 5 | 26.3 | 1.0 | Referent | - |
| GC | 19 | 42.2 | 3 | 18.8 | 0.258 | [0.062–1.080] | 0.066 * | 22 | 36.1 | 11 | 57.9 | 2.900 | [0.879–9.567] | 0.074 | |
| CC | 8 | 17.8 | 2 | 12.4 | 0.409 | [0.073–2.288] | 0.445 * | 10 | 16.4 | 3 | 15.8 | 1.740 | [0.351–8.633] | 0.666 * | |
| C carrier | 27 | 60.0 | 5 | 31.2 | 0.303 | [0.090–1.020] | 0.048 * | 32 | 53.5 | 14 | 73.7 | 2.538 | [0.813–7.919] | 0.102 | |
TRD: Treatment Resistant Depression. OR: odds ratio. CI: confidence interval. Significant p values in bold. * Fisher exact test.